منابع مشابه
Functional characterization of an abnormal factor XII molecule (F XII Bern).
An 18-year-old healthy woman was found to have cross-reacting material (CRM)-positive factor XII (F XII) deficiency, F XII clotting activity was less than 0.01 U/mL, whereas F XII antigen was 0.11 U/mL. An F XII inhibitor was excluded. To partially characterize the molecular defect of the abnormal F XII, immunologic and functional studies were performed on the proposita's plasma. The abnormal F...
متن کاملFactor XII Deficiency
Factor XII ia a single-chain beta-globulin serine protease with a molecular weight of 80,000 84,000 daltons and a plasma concentration of approximately 30 pg/mL. Proteolytic cleavage of factor XII is mediated by charged surfaces (glass, kaolin, cellite, dextran sulfate, endotoxin, urates, crude collagen, sulfatides), autoactivation, and kallikrein. Prekallikrein, factor XI, factor VII, plasmino...
متن کاملActivation of factor XII by dextran sulfate: the basis for an assay of factor XII.
A system was developed for studying the activation of factor XII (Hageman factor) in the presence of dextran sulfate (DS). Salient features of the system included low ionic strength (0.08), low concentration of factor XII (approximately 1/10,000 that in normal plasma), and an excess of exogenous prekallikrein (PK). In this system, factor XII was rapidly converted to the 80,000 molecular weight ...
متن کاملCharacterization of factor XII Tenri, a rare CRM-negative factor XII deficiency.
Factor XII Tenri (Y34C), a rare cross-reacting material (CRM)-negative factor XII deficiency, was identified in a 71-yr-old Japanese woman with angina pectoris. In the patient's plasma, factor XII activity and antigen levels were only 1.6% and 5.0%, respectively, of those seen in a normal subject. Immunoblot analysis showed that the secreted factor XII Tenri existed not only as a monomer (76 kD...
متن کاملEstimation of REV size and Determination of geo-mechanical properties of the rock mass in Sechahoon Anomaly XII Mine
REV size study was carried out for data of Sechahoon Anomaly XII mine by using discrete fracture network and distinct element method in order to characterize mechanical and behavioral properties of a highly jointed rock mass. By studying on scale dependency of mechanical properties of rock mass, REV size was determined. On the other hand, for continuum modeling of rock mass because of inherent ...
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ژورنال
عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis
سال: 1992
ISSN: 1424-8832,1424-8840
DOI: 10.1159/000216346